By mandating “Gold Standard” science, this order presents itself as an effort to restore trust in federally funded research as a public good. While it promotes principles aligned with strong research practices, applying these standards rigidly may undermine the production, use, interpretation, and communication of scientific data for biomedical, behavioral health, and social science fields. It grants political appointees in federal health agencies the authority to designate research on certain topics (like climate protection, infectious disease control, and health equity) as scientific misconduct and disqualify credible scientific findings as misleading. The order may be used by policymakers to dismiss scientific evidence as uncredible, inaccurate, or biased. It may also undermine confidence in prior scientific work, suggesting past research was flawed or untrustworthy. Scientific and clinical research is critical to the healthcare system and improving care. Due to health inequalities and social barriers to research participation, scientific and clinical research lacks diversity. Diversity in research reduces bias and informs treatment and its affects on different groups of people. While claiming to promote rigor, it risks sidelining equity focused scientific data and may create public confusion or distrust in important equity initiatives built on prior evidence. It also establishes internal processes within each agency to review potential violations, subjecting agency employees and contractors to potential disciplinary actions.